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  • The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in adults with a body mass index (BMI) greater than 27, so long as they also have problems with weight-related health concerns such as Tupe2 diabestes, high cholesterol levels and/or hypertension (hypertension).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so when an aid to quitting smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle which includes a reduced-calorie eating and working out, Contrave provides another treatment choice for chronic weight management for people who are obese or are overweight and also have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular exercising. Results from a clinical trial that enrolled patients without diabetes showed that patients had a normal weight loss of four years old.1% in contrast to participants who were given placebos) within a 12- month period, while a different study involving patients with diabetes had an average weight loss of 2% over treatment with placebo at 12 months.

    Using two separate drugs to lose weight can be very effective you will find combinations while watching FDA now awaiting approval. When dealing with fat loss and the individuals who go through it you need to err on the side of caution and allow FDA do its job and demand some investigation be done so the public is aware of the side effects and risks of the medications before we take them. Keep in mind that drug companies come in business to generate money and that they would say everything to keep people on the medications.

    Researchers discovered that participants using this drug for a year, lost excess weight within a month and have kept the weight off throughout the 56 weeks in the study. Contrave is a combination in the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which might be made up of several active ingredient, which may make them far better and safer.

    Combo-pilling will be the newest fad or in addition to this the newest into the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular could be the fact that since right now there aren't long term prescription weight loss supplements that have been authorized by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be licensed by the FDA.

    Seizures can be a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug may also raise blood pressure levels and heartbeat, and really should not be used in people with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

    The FDA also warned that Contrave can raise blood pressure levels and heart rate and must stop used in patients with uncontrolled high blood pressure levels, along with by a person with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients which has a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients towards the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation.

    To keep up with the most current articles from Wendi, the Indiana Addiction Recovery Examiner, click the subscribe link near the top of the page to get email notification when new submissions are published. Please leave a comment for virtually any article.